Kill, but don't be killed

To Kill but Not Be Killed: A Delicate Balance

Before launching a missile, it is necessary to design an efficient safety net for self-protection. In this issue of Cell, Ellermeier et al. (2006) describe the mechanism underlying a biological safety net for the soil bacterium Bacillus subtilis. This bacterium protects itself from a toxic protein it secretes by upregulating an immunity protein, which it does by sequestering a transcriptional r...

Activated, but not resting, T cells can be recognized and killed by syngeneic NK cells.

We demonstrate that IL-2-activated NK cells or lymphokine-activated killer cells recognize and kill syngeneic CD4(+) and CD8(+) T cells that have been activated by APCs. Induction with APC required TCR-specific Ag, and lysis was perforin mediated. Brefeldin A, which disrupts protein transport, inhibited the sensitivity induced by activation. In BALB/c, expression of NKG2D ligands correlated wit...

Politicians : be killed or survive Benno

In the course of history, a large number of politicians have been assassinated. To investigate this phenomenon, rational choice hypotheses are developed and tested using a large data set covering close to 100 countries over a period of 20 years. Several strategies, in addition to security measures, are shown to significantly reduce the probability of politicians being attacked or killed: extend...

‘be Polite, Be Professional, Be Prepared to Kill’: Counterinsurgency, Masculinity and British Military Doctrine

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“Not Everything That Is Faced Can Be Changed, but Nothing Can Be Changed Until It Is Faced”: A Response to Recent Commentaries